Molecular Mechanisms Underlying Autophagy-Mediated Treatment Resistance in Cancer
Identifieur interne : 000619 ( Main/Exploration ); précédent : 000618; suivant : 000620Molecular Mechanisms Underlying Autophagy-Mediated Treatment Resistance in Cancer
Auteurs : Cally J. Ho [Canada] ; Sharon M. Gorski [Canada]Source :
- Cancers [ 2072-6694 ] ; 2019.
Abstract
Despite advances in diagnostic tools and therapeutic options, treatment resistance remains a challenge for many cancer patients. Recent studies have found evidence that autophagy, a cellular pathway that delivers cytoplasmic components to lysosomes for degradation and recycling, contributes to treatment resistance in different cancer types. A role for autophagy in resistance to chemotherapies and targeted therapies has been described based largely on associations with various signaling pathways, including MAPK and PI3K/AKT signaling. However, our current understanding of the molecular mechanisms underlying the role of autophagy in facilitating treatment resistance remains limited. Here we provide a comprehensive summary of the evidence linking autophagy to major signaling pathways in the context of treatment resistance and tumor progression, and then highlight recently emerged molecular mechanisms underlying autophagy and the p62/KEAP1/NRF2 and FOXO3A/PUMA axes in chemoresistance.
Url:
DOI: 10.3390/cancers11111775
PubMed: 31717997
PubMed Central: 6896088
Affiliations:
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Gorski</name><affiliation><nlm:aff id="af1-cancers-11-01775">Canada’s Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, BC V5Z 1L3, Canada;<email>caho@bcgsc.ca</email></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-cancers-11-01775">Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC V5A 1S6, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC V5A 1S6</wicri:regionArea><wicri:noRegion>BC V5A 1S6</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af3-cancers-11-01775">Centre for Cell Biology, Development, and Disease, Simon Fraser University, Burnaby, BC V5A 1S6, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Cell Biology, Development, and Disease, Simon Fraser University, Burnaby, BC V5A 1S6</wicri:regionArea><wicri:noRegion>BC V5A 1S6</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31717997</idno><idno type="pmc">6896088</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896088</idno><idno type="RBID">PMC:6896088</idno><idno type="doi">10.3390/cancers11111775</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000904</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000904</idno><idno type="wicri:Area/Pmc/Curation">000904</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000904</idno><idno type="wicri:Area/Pmc/Checkpoint">000570</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000570</idno><idno type="wicri:Area/Ncbi/Merge">000B97</idno><idno type="wicri:Area/Ncbi/Curation">000B97</idno><idno type="wicri:Area/Ncbi/Checkpoint">000B97</idno><idno type="wicri:Area/Main/Merge">000619</idno><idno type="wicri:Area/Main/Curation">000619</idno><idno type="wicri:Area/Main/Exploration">000619</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Molecular Mechanisms Underlying Autophagy-Mediated Treatment Resistance in Cancer</title><author><name sortKey="Ho, Cally J" sort="Ho, Cally J" uniqKey="Ho C" first="Cally J." last="Ho">Cally J. Ho</name><affiliation><nlm:aff id="af1-cancers-11-01775">Canada’s Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, BC V5Z 1L3, Canada;<email>caho@bcgsc.ca</email></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-cancers-11-01775">Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC V5A 1S6, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC V5A 1S6</wicri:regionArea><wicri:noRegion>BC V5A 1S6</wicri:noRegion></affiliation></author><author><name sortKey="Gorski, Sharon M" sort="Gorski, Sharon M" uniqKey="Gorski S" first="Sharon M." last="Gorski">Sharon M. Gorski</name><affiliation><nlm:aff id="af1-cancers-11-01775">Canada’s Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, BC V5Z 1L3, Canada;<email>caho@bcgsc.ca</email></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-cancers-11-01775">Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC V5A 1S6, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC V5A 1S6</wicri:regionArea><wicri:noRegion>BC V5A 1S6</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af3-cancers-11-01775">Centre for Cell Biology, Development, and Disease, Simon Fraser University, Burnaby, BC V5A 1S6, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Cell Biology, Development, and Disease, Simon Fraser University, Burnaby, BC V5A 1S6</wicri:regionArea><wicri:noRegion>BC V5A 1S6</wicri:noRegion></affiliation></author></analytic><series><title level="j">Cancers</title><idno type="eISSN">2072-6694</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Despite advances in diagnostic tools and therapeutic options, treatment resistance remains a challenge for many cancer patients. Recent studies have found evidence that autophagy, a cellular pathway that delivers cytoplasmic components to lysosomes for degradation and recycling, contributes to treatment resistance in different cancer types. A role for autophagy in resistance to chemotherapies and targeted therapies has been described based largely on associations with various signaling pathways, including MAPK and PI3K/AKT signaling. However, our current understanding of the molecular mechanisms underlying the role of autophagy in facilitating treatment resistance remains limited. Here we provide a comprehensive summary of the evidence linking autophagy to major signaling pathways in the context of treatment resistance and tumor progression, and then highlight recently emerged molecular mechanisms underlying autophagy and the p62/KEAP1/NRF2 and FOXO3A/PUMA axes in chemoresistance.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Yu, L" uniqKey="Yu L">L. 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